(SOLVED) relationship between epidermal stem cells and skin carcinogenesis, Identify the major concepts associated with your subject.

Question

[ write a report according to the following questions under this relationship between epidermal stem cells and skin carcinogenesis]

a. Identify the major concepts associated with your subject, then consider the keywords you will use. Notice possible synonyms, alternative spellings, plurals and other endings.

b.Firstly, choose the databases which you can use; Secondly, choose databases and search tools as widely as possible, for example: the databases ordered by SMU, Internet Resources, journals or books collected by SMU Library.

c.Please write down your search process, including the search fields, search strategy, limits, etc.

d.Browse the search results, analyze and write down those relevant to your subject.

e.A literature review is an account of what has been published on a topic by accredited scholars and researchers. It is not just a descriptive list of the material available, or a set of summaries. Please give a literature review about your search title. Note: No less than 2000 words

Expert solution paper

The origin of the stem cells can be determined using cell topographical within the highly polarised surface epithelia. This can be fairly accurate in some cases, allowing researchers to study the features of stem cells. The current state of knowledge about the stem flow cytometry in the epidermis and crypts of mice is reviewed. Stem cells appear to make up about 10% of the basal layer in the epidermis and are dispersed towards to the centre of the epidermal proliferation unit's basal layer component. These cells have such a long cellular proliferation and are most likely the ones that store tritiated thymidine and highly radioactive labelled malignancies for extended periods of time. This label retention allows the presumed stem cell to be labelled.

In recent years, data revealing numerous sorts of variability within the stratum basale has accumulated, most of that can be understood in connection to cell hierarchy. Cell locations and the zone of stem cell can be determined very precisely in the small intestine. Each crypt includes from 4 and 16 steady - state condition functional stem cells, according to complex simulation of a variety of cell kinetic tests. Up to 32 individuals could be able of clonal reproduction, according to radiobiological research. The clonogenic cell segment repopulation was determined, and the double time was found to be 19.7 hours. Such research should shed more light on stem cell behaviour and pinpoint the time of times of excessive and decreased activity.

The relationship between epidermal stem cells and skin carcinogenesis.

Because stem cells live for far longer than conventional cells, they are more likely to collect genetic mutations. It may only take a few mutations for a cell to lose power of its self-renewal and development, allowing it to become a cancerous source.